Article

Longitudinal Analysis Over Decades Reveals the Development and Immune Implications of Type I Interferon Autoantibodies in an Aging Population

2024-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Pre-existing autoantibodies (autoAbs) neutralizing type I interferons (IFN-Is: IFNα, IFNβ, IFNω) have recently been described as significant contributors to the severity of viral infectious diseases. Here, we explore the development and consequences of anti-IFN-I autoAbs at high-resolution using retrospective samples and data from 1876 well-treated individuals >65 years of age enrolled in the Swi...

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Literature Corpus work: fe60a55d-18ed-5b6d-8e0d-298d585c3fed
DOI: 10.1101/2024.02.27.24303363

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