Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interferon system deficiencies exacerbating severe pandemic virus infections.

Trends in microbiology - 1 Nov 2021

Stertz Silke, Hale Benjamin G

Abstract excerpt

Pandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Autoantibodies
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Resistance

Share to Host-Pathogen Interactions

Share to Interferons

Share to Loss of Function Mutation

Share to Virus Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 33757684
DOI: 10.1016/j.tim.2021.03.001
PMCID: PMC7980109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interferon system deficiencies exacerbating severe pandemic virus infections.PMID 33757684Read ↗

Interfering with Interferons: A Critical Mechanism for Critical COVID-19 PneumoniaSemantic proximity Read ↗

Type I and III IFN-mediated antiviral actions counteracted by SARS-CoV-2 proteins and host inherited factors.Semantic proximity Read ↗

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19Semantic proximity Read ↗

Neutralizing Type I Interferon Autoantibodies in Japanese Patients With Severe COVID-19Semantic proximity Read ↗

The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodiesSemantic proximity Read ↗

Interferon Resistance of Emerging SARS-CoV-2 VariantsSemantic proximity Read ↗

Defective type I interferon immunity is associated with increasing COVID-19 severitySemantic proximity Read ↗

Interferon resistance of emerging SARS-CoV-2 variantsSemantic proximity Read ↗

Role of interferons in the antiviral battle: from virus-host crosstalk to prophylactic and therapeutic potential in SARS-CoV-2 infectionSemantic proximity Read ↗

Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 PatientsSemantic proximity Read ↗

Type I interferons and SARS-CoV-2: from cells to organismsSemantic proximity Read ↗

Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.