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Article

Heterogeneity and functions of the 13 IFN‐α subtypes – lucky for some?

27 Jun 2023

Abstract excerpt

Type I IFNs are critical for host responses to viral infection and are also implicated in the pathogenesis of multiple autoimmune diseases. Multiple subtypes exist within the type I IFN family, in particular 13 distinct IFN-α genes, which signal through the same heterodimer receptor that is ubiquitously expressed by mammalian cells. Both evolutionary genetic studies and functional antiviral assays strongly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37367434
DOI: 10.1002/eji.202250307

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