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Type I interferons in health and disease: molecular aspects and clinical implications

10 Jul 2025

Abstract excerpt

Type I interferons (IFNs), particularly IFNα and IFNβ, play a crucial role in the human immune response against viral infections. This review delves into the multifaceted antiviral, immunomodulatory, and antitumor physiological roles of type I IFNs, while describing their contribution to the pathogenesis of various disease pathologies including cancer, systemic and organ-specific autoimmunity, neuroinflammation,...

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PMID: 40637491
DOI: 10.1152/physrev.00047.2024

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