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Article

Single luminal epithelial progenitors can generate prostate organoids in culture.

Nature cell biology - 1 Oct 2014

Chua Chee Wai, Shibata Maho, Lei Ming, Toivanen Roxanne, Barlow LaMont J, Bergren Sarah K, Badani Ketan K, McKiernan James M, Benson Mitchell C, Hibshoosh Hanina, Shen Michael M

Abstract excerpt

The intrinsic ability to exhibit self-organizing morphogenetic properties in ex vivo culture may represent a general property of tissue stem cells. Here we show that single luminal stem/progenitor cells can generate prostate organoids in a three-dimensional culture system in the absence of stroma. Organoids generated from CARNs (castration-resistant Nkx3.1-expressing cells) or normal prostate epithelia exhibit...

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Identifiers

PMID: 25241035
DOI: 10.1038/ncb3047
PMCID: PMC4183706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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