Article

TGFβ in the obese liver mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype

2019-03-14

Abstract excerpt

The liver contains both NK cells and their less cytotoxic relatives, ILC1. Here, we investigate the role of NK cells and ILC1 in the obesity-associated condition, non-alcoholic fatty liver disease (NAFLD). In the livers of mice suffering from NAFLD, NK cells are less able to degranulate, express lower levels of perforin and are less able to kill cancerous target cells than those from healthy animals. This is assoc...

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Literature Corpus work: fe52b590-14c7-5b92-98b6-b3fd5b582041
DOI: 10.1101/576538

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