Article
Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight.
Cell metabolism - 1 Jan 2010
Alekseev Alexey E, Reyes Santiago, Yamada Satsuki, Hodgson-Zingman Denice M, Sattiraju Srinivasan, Zhu Zhiyong, Sierra Ana, Gerbin Marina, Coetzee William A, Goldhamer David J, Terzic Andre, Zingman Leonid V
Abstract excerpt
Metabolic processes that regulate muscle energy use are major determinants of bodily energy balance. Here, we find that sarcolemmal ATP-sensitive K(+) (K(ATP)) channels, which couple membrane excitability with cellular metabolic pathways, set muscle energy expenditure under physiological stimuli. Disruption of K(ATP) channel function provoked, under conditions of unaltered locomotor activity and blood substrate...
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