Article

SwiftMHC: A High-Speed Attention Network for MHC-Bound Peptide Identification and 3D Modeling

2025-01-22

Abstract excerpt

Identifying tumor peptides that bind patient MHC proteins and elicit immune responses is central to immunotherapy, yet progress remains limited to a handful of well-studied alleles. Structure-based methods generalize better than sequence-only models but are constrained by the high computational cost of 3D modeling. We present SwiftMHC, the fastest structure-based framework for peptide–MHC (pMHC) modeling and bindi...

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Literature Corpus work: 5390beac-4ef3-5c34-b900-3212719fce30
DOI: 10.1101/2025.01.20.633893

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