Article

STRUMP-I: Structure-based machine learning approach to pMHC-I binding prediction using force field energy features

2025-09-08

Abstract excerpt

The adaptive immune system monitors cellular integrity by recognizing short peptides from intracellular proteins presented on Major Histocompatibility Complex class I (MHC-I) molecules, collectively termed peptide-MHC complexes (pMHC), enabling detection of foreign or mutated proteins. With the rising importance of immunotherapies targeting neoantigens in cancers, the ability to accurately predict which peptides w...

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Literature Corpus work: 5ed2b137-2d92-56a6-bd92-eb6ca4d9c654
DOI: 10.1101/2025.09.03.674126

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