Article

ProtSyntax: a protein large language model for decoding post-translational modification syntax and function

2026-08-06

Abstract excerpt

<title>Abstract</title> <p>Post-translational modifications (PTMs) expand protein function by encoding context-dependent regulatory states, and their dysregulation contributes to cancer, neurodegeneration disease. However, existing methods treat PTMs as independent residue labels, limiting their ability to distinguish contextually permissible sites, model crosstalk and infer functional consequences. Here we intro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 09d8ee72-f2fd-5046-8ff0-99e127c7c25a
DOI: 10.21203/rs.3.rs-10567634/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ProtSyntax: a protein large language model for decoding post-translational modification syntax and functionDOI 10.21203/rs.3.rs-10567634/v1Read

ProtSyntax: a protein large language model for decoding post-translational modification syntax and functionSemantic proximity Read

Post-Translational Modification Prediction via Prompt-Based Fine-Tuning of a GPT-2 ModelSemantic proximity Read

Interpreting Protein Language Models: high attention sites predict functional regionsSemantic proximity Read

InstructPLM: Aligning Protein Language Models to Follow Protein Structure InstructionsSemantic proximity Read

InstructPLM: Aligning Protein Language Models to Follow Protein Structure InstructionsSemantic proximity Read

Pretrained protein language models choose between sequence novelty and structural completenessSemantic proximity Read

MetalTrans: A Biological Language Model-Based Approach for Predicting Disease-Associated Mutations in Protein Metal-Binding Sites.Semantic proximity Read

Learning residue-level context for modeling protein-protein interactionsSemantic proximity Read

Dynamics-aware geometric learning predicts disease-associated molecular perturbationsSemantic proximity Read

Mixture of Experts Enable Efficient and Effective Protein Understanding and DesignSemantic proximity Read

Pool PaRTI: A PageRank-Based Pooling Method for Identifying Critical Residues and Enhancing Protein Sequence RepresentationsSemantic proximity Read

Applying Protein Language Models Using Limited Dataset. Sequence-Based Hot Spot Prediction in Protein Interactions Using AutoGluonSemantic proximity Read