Article

AP2A1 is upregulated upon replicative senescence of human fibroblasts to strengthen focal adhesions via integrin β1 translocation along stress fibers

2023-08-20

Abstract excerpt

Aging proceeds with accumulation of senescent cells in multiple organs. Senescent cells become large in size compared to young cells, which promotes further senescence and age-related diseases. Currently, the molecular mechanism behind the maintenance of such huge cell architecture undergoing senescence remains poorly understood. Here we focus on reorganization of actin stress fibers induced upon replicative senes...

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Literature Corpus work: 46fd9525-6d61-5f14-b4e9-a6fab6e0bec5
DOI: 10.1101/2023.08.19.553998

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