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Article

AP2A1 modulates cell states between senescence and rejuvenation

21 Jan 2025

Abstract excerpt

Aging proceeds with the accumulation of senescent cells in multiple organs. These cells exhibit increased size compared to young cells, which promotes further senescence and age-related diseases. Currently, the molecular mechanism behind the maintenance of such huge cell architecture undergoing senescence remains poorly understood. Here we focus on the reorganization of actin stress fibers induced upon...

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PMID: 39848456
DOI: 10.1016/j.cellsig.2025.111616

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