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Article

Stiffness and Aging in Cardiovascular Diseases: The Dangerous Relationship between Force and Senescence

26 Mar 2021

Abstract excerpt

Biological aging is a process associated with a gradual decline in tissues' homeostasis based on the progressive inability of the cells to self-renew. Cellular senescence is one of the hallmarks of the aging process, characterized by an irreversible cell cycle arrest due to reactive oxygen species (ROS) production, telomeres shortening, chronic inflammatory activation, and chromatin modifications. In this review,...

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PMID: 33810253
DOI: 10.3390/ijms22073404

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