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Article

Synthetic lethality on drug discovery: an update on cancer therapy.

Expert opinion on drug discovery - 1 Jul 2020

Yar M Shahar, Haider Kashif, Gohel Vivek, Siddiqui Nasir Ali, Kamal Ahmed

Abstract excerpt

INTRODUCTION: A novel anticancer therapy is the need of the hour due to growing incidences of resistance to first line cancer chemotherapy. Synthetic lethality (SL) is one of the new age treatment methods being explored for combating the resistance to anticancer agents. In this method, cell mutations are exploited for the development of new therapeutic agents, where, if there is loss of function of one gene, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32228106
DOI: 10.1080/17460441.2020.1744560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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