Article
Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation.
Nature genetics - 1 Mar 2021
Jerber Julie, Seaton Daniel D, Cuomo Anna S E, Kumasaka Natsuhiko, Haldane James, Steer Juliette, Patel Minal, Pearce Daniel, Andersson Malin, Bonder Marc Jan, Mountjoy Ed, Ghoussaini Maya, Lancaster Madeline A, Marioni John C, Merkle Florian T, Gaffney Daniel J, Stegle Oliver
Abstract excerpt
Studying the function of common genetic variants in primary human tissues and during development is challenging. To address this, we use an efficient multiplexing strategy to differentiate 215 human induced pluripotent stem cell (iPSC) lines toward a midbrain neural fate, including dopaminergic neurons, and use single-cell RNA sequencing (scRNA-seq) to profile over 1 million cells across three differentiation...
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