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Inducible transgene expression in PDX models <i>in vivo</i> identifies KLF4 as therapeutic target for B-ALL

2019-08-16

Abstract excerpt

Clinic-close methods are not available that prioritize and validate potential therapeutic targets in individual tumors from the vast bulk of descriptive expression data. We developed a novel technique to express transgenes in established patient-derived xenograft (PDX) models in vivo to fill this gap. With this technique at hand, we analyzed the role of transcription factor Krüppel-like factor 4 (KLF4) in B-cell...

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Literature Corpus work
4b32f821-eb46-5eda-a911-6c8a98c5c466
DOI
10.1101/737726
Open publication

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Inducible transgene expression in PDX models <i>in vivo</i> identifies KLF4 as therapeutic target for B-ALLDOI 10.1101/737726
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