Article

CRISPR/Cas9 technology abolishes the <i>BCR/ABL1</i> oncogene in chronic myeloid leukemia and restores normal hematopoiesis

2020-08-05

Abstract excerpt

<h4>ABSTRACT</h4> Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease produced by a unique oncogenic event involving the constitutively active tyrosine kinase (TK) BCR/ABL1 . TK activity explains most features of CML, such as tumor development and maintenance. TK-inhibitory (TKI) drugs have changed its prognosis and natural history. Unfortunately, the ABL1 gene persists unaffected by TKIs, leuke...

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Literature Corpus work: 4ad43e6e-140b-5272-aa7a-3308b68ce077
DOI: 10.1101/2020.08.05.237610

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