Article

Development of a Multi-Trait Polygenic Score for Intrinsic Capacity

2026-02-27

Abstract excerpt

<h4>Background</h4> Intrinsic capacity (IC) is a key marker of healthy ageing, which captures an individual’s physical and mental capacities, measured across five domains: cognitive, locomotor, psychological, vitality, and sensory. Although genetic factors are known to influence both general IC and its individual domains, existing IC indices have been developed primarily using phenotypic data, without accounting...

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Literature Corpus work: fdc1e1a9-e7e4-5e08-9084-a6064312e1fe
DOI: 10.64898/2026.02.25.26347054

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