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Article

Polygenic scores and physical fitness prediction: a systematic review.

Human genetics - 21 Mar 2026

Rami Farzaneh, Vaziri Nazanin, Tyndall Amanda V, Anderson David W, Poulin Marc J, Bousman Chad A

Abstract excerpt

Polygenic scores (PGS) have emerged as a promising tool for understanding the genetic underpinnings of physical fitness traits, including aerobic fitness (also called cardiorespiratory fitness), muscular fitness and adiposity, and neuromotor performance (including agility/speed-related parameters). However, the predictive utility of PGS for physical fitness traits is unclear. To address this knowledge gap, we...

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PMID: 41863561
DOI: 10.1007/s00439-026-02820-x

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