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Phenotype correlations reveal the relationships of physiological systems underlying human ageing.

Aging cell - 1 Dec 2021

Hao Meng, Zhang Hui, Hu Zixin, Jiang Xiaoyan, Song Qi, Wang Xi, Wang Jiucun, Liu Zuyun, Wang Xiaofeng, Li Yi, Jin Li

Abstract excerpt

Ageing is characterized by degeneration and loss of function across multiple physiological systems. To study the mechanisms and consequences of ageing, several metrics have been proposed in a hierarchical model, including biological, phenotypic and functional ageing. In particular, phenotypic ageing and interconnected changes in multiple physiological systems occur in all ageing individuals over time. Recently,...

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PMID: 34825761
DOI: 10.1111/acel.13519
PMCID: PMC8672793

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