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Article

A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.

The journals of gerontology. Series A, Biological sciences and medical sciences - 5 Oct 2025

Beyene Melkamu B, Visvanathan Renuka, Alemu Robel, Benyamin Beben, Bhattacharjee Rudrarup, Beyene Habtamu B, Theou Olga, Cesari Matteo, Beard John R, Amare Azmeraw T

Abstract excerpt

BACKGROUND: Intrinsic capacity (IC) is a multidimensional concept within the World Health Organization framework for healthy aging. It refers to the composite of an individual's physical and mental capacities that enable them to maintain well-being, functional ability, and engagement in valued activities throughout life. While substantial evidence supports the biological basis of IC and its subdomains, the extent...

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PMID: 41066301
DOI: 10.1093/gerona/glaf196
PMCID: PMC12510315

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