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Article

Physiological Phenotypic Aging Index and Its Association With Health, Functional, and Health Care Outcomes in Older Adults: Findings From the UK Biobank.

Journal of the American Medical Directors Association - 1 Dec 2025

Lee Sol, Lee Yunhwan, Jeong Yeonbin, Kim Jungeun

Abstract excerpt

OBJECTIVES: This study aimed to analyze the associations of the Phenotypic Aging Index (PAI) with health outcomes, functional outcomes, and health care utilization using UK Biobank data. Specifically, we assessed whether the PAI predicts these outcomes after adjusting for polygenic risk scores (PRS) and demographic and socioeconomic variables. DESIGN: This was a prospective cohort study with no intervention....

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PMID: 41106428
DOI: 10.1016/j.jamda.2025.105927

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