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Article

Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2024

Herranen Päivi, Koivunen Kaisa, Palviainen Teemu, Kujala Urho M, Ripatti Samuli, Kaprio Jaakko, Sillanpää Elina, FinnGen

Abstract excerpt

BACKGROUND: We used a polygenic score for hand grip strength (PGS HGS) to investigate whether genetic predisposition for higher muscle strength predicts age-related noncommunicable diseases, survival from acute adverse health events, and mortality. METHODS: This study consisted of 342 443 Finnish biobank participants from FinnGen Data Freeze 10 (53% women) aged 40-108 with combined genotype and health registry...

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Identifiers

PMID: 38450701
DOI: 10.1093/gerona/glae064
PMCID: PMC10972579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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