Article

Loss of chromosome cytoband 13q14.2 orchestrates breast cancer pathogenesis and drug response

2024-06-20

Abstract excerpt

Breast cancer (BCa) is a major global health challenge, characterized by chromosomal instability (CIN) and subsequent acquisition of extensive somatic copy number alterations (CNAs). CNAs including amplifications and deletions, significantly influence intra-tumor heterogeneity and the tumor microenvironment (TME). Among these, the loss of chromosome 13q14.2 emerges as a considerable factor in BCa pathogenesis and...

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Literature Corpus work: fd80ddaf-d494-5b71-973c-cc1a5849d99d
DOI: 10.1101/2024.06.18.599481

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