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Article

DNA amplifications in breast cancer: genotypic-phenotypic correlations.

Future oncology (London, England) - 1 Jun 2010

Shiu Kai-Keen, Natrajan Rachael, Geyer Felipe C, Ashworth Alan, Reis-Filho Jorge S

Abstract excerpt

DNA copy number changes in cancer cells, in particular, amplifications, occur frequently, have prognostic impact and are associated with subtypes of breast cancer. Some amplicons contain well-characterized oncogenes, including 11q13 (CCND1) and 17q12 (HER2). HER2 amplification and overexpression defines the HER2+ subgroup of breast cancer patients and is both a prognostic marker for poor outcome and a predictive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20528234
DOI: 10.2217/fon.10.56

Genes

CCND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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