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Integrative analysis identifies two molecular and clinical subsets in Luminal B breast cancer

27 Jul 2023

Abstract excerpt

Comprehensive multiplatform analysis of Luminal B breast cancer (LBBC) specimens identifies two molecularly distinct, clinically relevant subtypes: Cluster A associated with cell cycle and metabolic signaling and Cluster B with predominant epithelial mesenchymal transition (EMT) and immune response pathways. Whole-exome sequencing identified significantly mutated genes including TP53 , PIK3CA , ERBB2 , and GATA3...

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PMID: 37636034
DOI: 10.1016/j.isci.2023.107466

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