Drug-target binding quantitatively predicts optimal antibiotic dose levels

Abstract excerpt

Combatting antibiotic resistance will require both new antibiotics and strategies to preserve the effectiveness of existing drugs. Both approaches would benefit from predicting optimal dosing of antibiotics based on drug-target binding parameters that can be measured early in drug development and that can change when bacteria become resistant. This would avoid the currently frequently employed trial-and-error appr...

Topics

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• Anti-Bacterial Agents
• Drug Design
• Drug Resistance, Bacterial
• Escherichia coli
• Gram-Positive Bacteria
• Models, Theoretical
• Mutation
• Ribosomes

Identifiers and source

Literature Corpus work

fd496a5f-c67b-5e37-b7d3-e55341956e3c

DOI

10.1101/369975