Article

Growth‐mediated negative feedback shapes quantitative antibiotic response

2020-12-28

Abstract excerpt

Dose‐response relationships are a general concept for quantitatively describing biological systems across multiple scales, from the molecular to the whole‐cell level. A clinically relevant example is the bacterial growth response to antibiotics, which is routinely characterized by dose‐response curves. The shape of the dose‐response curve varies drastically between antibiotics and plays a key role for treatments,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76db0d22-51c2-52ae-b2c4-c7c57d8e048e
DOI: 10.1101/2020.12.28.424579

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Growth‐mediated negative feedback shapes quantitative antibiotic responseDOI 10.1101/2020.12.28.424579Read

Adaptation and compensation in a bacterial gene regulatory network evolving under antibiotic selection.Semantic proximity Read

Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics.Semantic proximity Read

Quantifying the Determinants of Evolutionary Dynamics Leading to Drug Resistance.Semantic proximity Read

Pervasive gene deregulation underlies adaptation and maladaptation in trimethoprim-resistant E. coli.Semantic proximity Read

Pervasive and diverse collateral sensitivity profiles inform optimal strategies to limit antibiotic resistance.Semantic proximity Read

A trimethoprim derivative impedes antibiotic resistance evolution.Semantic proximity Read

Metabolic fitness landscapes predict the evolution of antibiotic resistance.Semantic proximity Read

Antibiotic perseverance increases the risk of resistance development.Semantic proximity Read

Genetic architecture of intrinsic antibiotic susceptibility.Semantic proximity Read

Systematic discovery of drug interaction mechanisms.Semantic proximity Read

Agrichemicals boost the effects of antibiotics on antibiotic resistance evolutionSemantic proximity Read

Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells.Semantic proximity Read