Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modelling biphasic killing of fluoroquinolones: guiding optimal dosing regimen design.

The Journal of antimicrobial chemotherapy - 1 May 2011

Bhagunde Pratik, Singh Renu, Ledesma Kimberly R, Chang Kai-Tai, Nikolaou Michael, Tam Vincent H

Abstract excerpt

OBJECTIVES: Fluoroquinolones are commonly believed to exhibit concentration-dependent killing, but time-kill studies have revealed that fluoroquinolone activity could be a complex combination of concentration-dependent and -independent killing. We had previously developed a mathematical modelling framework to describe the dynamics of bacterial populations under the effect of antimicrobials, which could facilitate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fluoroquinolones
Share to Aza Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Levofloxacin

Share to Microbial Viability

Share to Models, Theoretical

Share to Moxifloxacin

Share to Ofloxacin

Share to Quinolines

Source

Identifiers

PMID: 21393141
DOI: 10.1093/jac/dkr054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modelling biphasic killing of fluoroquinolones: guiding optimal dosing regimen design.PMID 21393141Read ↗

Bacterial Replication Rate Modulation in Combination with Antimicrobial Therapy: Turning the Microbe against Itself.Semantic proximity Read ↗

Use of an in vitro pharmacodynamic model to derive a moxifloxacin regimen that optimizes kill of Yersinia pestis and prevents emergence of resistance.Semantic proximity Read ↗

Mathematical Modeling of Escherichia coli Kinetics to Predict Growth and Rifampicin-dependent Killing ProfileSemantic proximity Read ↗

Pharmacodynamics of fosfomycin: insights into clinical use for antimicrobial resistance.Semantic proximity Read ↗

Crossing the Chasm: How to Approach Translational Pharmacokinetic–Pharmacodynamic Modeling of Phage DosingSemantic proximity Read ↗

Dose-related selection of fluoroquinolone-resistant Escherichia coli.Semantic proximity Read ↗

A General Analytic Approach to Predicting the Best Antibiotic Dosing RegimenSemantic proximity Read ↗

Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae.Semantic proximity Read ↗

Antibiotic resistance--what's dosing got to do with it?Semantic proximity Read ↗

Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations.Semantic proximity Read ↗

Time-dependent pharmacodynamics of amikacin on Mycobacterium abscessus growth and resistance emergenceSemantic proximity Read ↗

[Pharmacodynamic and pharmacokinetic evaluation of respiratory fluoroquinolones. Guideline to selection of the most appropriate fluoroquinolone].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.