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Article

BactProNET: a structural-mechanistic platform for interpreting target-mediated antimicrobial resistance.

Scientific reports - 20 May 2026

Wang Ke, Liu Yiru, Wang Xue, Zhou Haitao, Chen Longfei, Xu Jingyun

Abstract excerpt

Antibiotics are the frontline therapy for bacterial infections, yet their efficacy is critically threatened by antimicrobial resistance (AMR), a crisis largely driven by mutations in protein targets. While this mechanism is prevalent, data on its structural impact remains highly dispersed, and existing resources such as CARD, ResFinder, MEGARes, and NDARO prioritize gene identification over mechanistic insight....

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Identifiers

PMID: 42162213
DOI: 10.1038/s41598-026-53667-1
PMCID: PMC13392442

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