A General Analytic Approach to Predicting the Best Antibiotic Dosing Regimen

Abstract excerpt

Determining optimal antibiotic dosing strategies is complex. Clinically, some antibiotics work best in continuous low doses, while others require high repeated pulses. However, a rational understanding of the best approach depending on the specific pairing of antibiotic and bacterial species remains unclear. Using mathematical models, we analyze bacterial populations under two strategies – constant concentration a...

Topics

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• Anti-Bacterial Agents
• Bacterial Infections
• Computer Simulation
• Drug Administration Schedule
• Drug Resistance, Bacterial
• Drug Therapy, Combination
• Microbial Sensitivity Tests
• Models, Biological

Identifiers and source

Literature Corpus work

a9e4052c-abb9-533c-9bff-c76ca3906c4c

DOI

10.1101/2025.09.13.676026