Article

Reduced complexity of brain and behavior due to MeCP2 disruption and excessive inhibition

2020-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome (RTT) is a devastating neurodevelopmental disorder, caused by disruptions to the MECP2 gene, and resulting in severe cognitive and motor impairment. Previous work strongly suggests that healthy MECP2 function is required to have a normal balance between excitatory and inhibitory neurons. However, the details of how neural circuit dynamics and motor function are disrupted remain unc...

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Literature Corpus work: fd3cfd7f-b718-5e9b-8597-35e5e672099d
DOI: 10.1101/2020.12.29.424632

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