Article

Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett Syndrome Mice

2023-10-02

Abstract excerpt

Rett Syndrome (RTT) is a severe neurodevelopmental disorder that mainly affects girls and women due to silencing mutations in the X-linked MECP2 gene. One of the most troubling symptoms of RTT is breathing irregularity, including apneas, breath-holds, and hyperventilation. Mice with silencing mutations in Mecp2 exhibit breathing abnormalities similar to human patients and serve as useful models for studying mech...

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Literature Corpus work: 1e4e2564-4840-5ab9-ac92-20f912bd2a45
DOI: 10.1101/2023.10.02.560501

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