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Article

<i>MECP2</i> duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autism

2019-08-07

Abstract excerpt

MECP2 gain- and loss-of-function in genetically-engineered monkeys demonstrably recapitulate typical phenotypes in patients, yet where MECP2 mutation affects the monkey brain and whether/how it relates to autism pathology remains unknown. Using expression profiles of 13,888 genes in 182 macaque neocortical samples, we first show that MECP2 coexpressed genes are enriched in GABA-related signaling pathways. We the...

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Literature Corpus work
a75e7f14-0dd4-5f67-be81-5bef4e5a1032
DOI
10.1101/728113
Open publication

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<i>MECP2</i> duplication causes aberrant GABA pathways, circuits and behaviors in transgenic monkeys: neural mappings to patients with autismDOI 10.1101/728113
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