Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired spatial memory codes in a mouse model of Rett syndrome.

eLife - 20 Jul 2018

Kee Sara E, Mou Xiang, Zoghbi Huda Y, Ji Daoyun

Abstract excerpt

The Mecp2+/- mouse model recapitulates many phenotypes of patients with Rett syndrome (RTT), including learning and memory deficits. It is unknown, however, how the disease state alters memory circuit functions in vivo in RTT mice. Here we recorded from hippocampal place cells, which are thought to encode spatial memories, in freely moving RTT mice and littermate controls. We found that place cells in RTT mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mice
Share to Mice, Knockout
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Memory Disorders

Share to Methyl-CpG-Binding Protein 2

Share to Neuronal Plasticity

Share to Rett Syndrome

Source

Open in PubMed Open full text

Identifiers

PMID: 30028675
DOI: 10.7554/eLife.31451
PMCID: PMC6054527

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired spatial memory codes in a mouse model of Rett syndrome.PMID 30028675Read ↗

Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett SyndromeSemantic proximity Read ↗

Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model.Semantic proximity Read ↗

Hippocampal place cell sequences are impaired in a rat model of Fragile X SyndromeSemantic proximity Read ↗

MeCP2 deficiency impairs motor cortical circuit flexibility associated with motor learning.Semantic proximity Read ↗

mPFC pyramidal neuron synchrony during social competition to form social rankings is disrupted in male Mecp2 knockout miceSemantic proximity Read ↗

mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.Semantic proximity Read ↗

Reduced complexity of brain and behavior due to MeCP2 disruption and excessive inhibitionSemantic proximity Read ↗

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome.Semantic proximity Read ↗

Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged <i> App <sup>NL-G-F</sup> </i> miceSemantic proximity Read ↗

Hippocampal circuit abnormalities in MeCP2+/- mouse model of Rett syndromeSemantic proximity Read ↗

Remembering the gist of an event over a lifetime depends on the hippocampusSemantic proximity Read ↗

Loss of MeCP2 leads to sleep deficits that are time-of-day dependent and worsen with sleep deprivationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.