Article

Hyperexcitability in human <i>MECP2</i> null neuronal networks manifests as calcium-dependent reverberating super bursts

2023-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome (RTT) patients show abnormal developmental trajectories including loss of language and repetitive hand movements but also have signs of cortical hyperexcitability such as seizures. RTT is predominantly caused by mutations in MECP2 and can be modelled in vitro using human stem cell-derived neurons. MECP2 null excitatory neurons are smaller in soma size and have reduced synaptic co...

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Literature Corpus work: ed5c1dd3-2a0f-51c6-9550-c3b328231f4f
DOI: 10.1101/2023.09.12.557388

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