Article
Functional differences between neurotransmitter binding sites of muscle acetylcholine receptors.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014
Nayak Tapan K, Bruhova Iva, Chakraborty Srirupa, Gupta Shaweta, Zheng Wenjun, Auerbach Anthony
Abstract excerpt
A muscle acetylcholine receptor (AChR) has two neurotransmitter binding sites located in the extracellular domain, at αδ and either αε (adult) or αγ (fetal) subunit interfaces. We used single-channel electrophysiology to measure the effects of mutations of five conserved aromatic residues at each site with regard to their contribution to the difference in free energy of agonist binding to active versus resting...
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