Article

Structural and temporal basis for agonism in the α4β2 nicotinic acetylcholine receptor

2022-02-24

Abstract excerpt

Despite decades of study, the structural mechanisms underpinning agonist efficacy in pentameric ligand-gated ion channels remain poorly understood. Here, a combination of extensive equilibrium and dynamical-nonequilibrium molecular dynamics simulations was used to obtain a detailed description of the structural and dynamic changes induced within the human α4β2 nicotinic acetylcholine receptor by a full and a parti...

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Literature Corpus work: b9893bd0-860d-5ecf-b3aa-8e7fef74166a
DOI: 10.1101/2022.02.23.481608

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Structural and temporal basis for agonism in the α4β2 nicotinic acetylcholine receptorDOI 10.1101/2022.02.23.481608Read

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