The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.

doi:10.1002/neu.10153

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences.

Journal of neurobiology - 1 Dec 2002

Le Novère Nicolas, Corringer Pierre-Jean, Changeux Jean-Pierre

Abstract excerpt

Nicotinic acetylcholine receptors are made up of homologous subunits, which are encoded by a large multigene family. The wide number of receptor oligomers generated display variable pharmacological properties. One of the main questions underlying research in molecular pharmacology resides in the actual role of this diversity. It is generally assumed that the observed differences between the pharmacology of...

Topics

Acetylcholine
Animals
Biological Evolution
Genetic Variation
Humans
Protein Subunits
Receptors, Nicotinic

Source

Open in PubMed

Identifiers

PMID: 12436412
DOI: 10.1002/neu.10153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics