Article

Structural correlates of human muscle nicotinic acetylcholine receptor subunit assembly mediated by δ(+) interface residues

2020-06-12

Abstract excerpt

Muscle nicotinic acetylcholine receptors are a class of heteropentameric ligand-gated cation channels with constituent subunits adopting a fixed stoichiometric arrangement. The specific amino acid residues that govern subunit ordering are however, only partially understood. By integrating all-atom molecular dynamics simulations, bioinformatics, two-electrode voltage clamp electrophysiology and 125 I-α-bungarotoxi...

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Literature Corpus work: 6f12e95d-227a-500f-bb5b-c8dafd6afd88
DOI: 10.1101/2020.06.11.145466

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