Article

Specificity of a polygenic score for aggressive prostate cancer

2025-01-25

Abstract excerpt

To address the concern that polygenic hazard scores for prostate cancer (PCa) might not distinguish between indolent and aggressive disease, we performed case-only analyses using a 601-variant polygenic score (PHS601). We hypothesized that among men who eventually developed PCa, those with higher PHS were more likely to develop aggressive disease. We analyzed genetic and phenotypic data from a diverse, national...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fd148278-e0f2-5f6a-a830-ee997b7e80ab
DOI: 10.1101/2025.01.23.25321041

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Specificity of a polygenic score for aggressive prostate cancerDOI 10.1101/2025.01.23.25321041Read

Germline polygenic score for prostate cancer aggressivenessSemantic proximity Read

Prostate cancer risk prediction using polygenic hazard scores in Norwegian populationsSemantic proximity Read

A genetic risk score to guide age-specific, personalized prostate cancer screeningSemantic proximity Read

Common genetic and clinical risk factors: Association with fatal prostate cancer in the Cohort of Swedish MenSemantic proximity Read

Clinical features of prostate cancer by polygenic risk score.Semantic proximity Read

A polygenic two-hit hypothesis for prostate cancer.Semantic proximity Read

Common genetic and clinical risk factors: association with fatal prostate cancer in the Cohort of Swedish Men.Semantic proximity Read

Polygenic Risk Scores in Prostate Cancer Risk Assessment and Screening.Semantic proximity Read

Genetic Risk Assessment of Lethal Prostate Cancer Using Polygenic Risk Score and Hereditary Cancer Susceptibility genesSemantic proximity Read

Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts.Semantic proximity Read

Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes.Semantic proximity Read

Precision Prostate Cancer Screening with a Polygenic Risk ScoreSemantic proximity Read