Article
A polygenic two-hit hypothesis for prostate cancer.
Journal of the National Cancer Institute - 11 Apr 2023
Houlahan Kathleen E, Livingstone Julie, Fox Natalie S, Kurganovs Natalie, Zhu Helen, Sietsma Penington Jocelyn, Jung Chol-Hee, Yamaguchi Takafumi N, Heisler Lawrence E, Jovelin Richard, Costello Anthony J, Pope Bernard J, Kishan Amar U, Corcoran Niall M, Bristow Robert G, Waszak Sebastian M, Weischenfeldt Joachim, He Housheng H, Hung Rayjean J, Hovens Christopher M, Boutros Paul C
Abstract excerpt
Prostate cancer is one of the most heritable cancers. Hundreds of germline polymorphisms have been linked to prostate cancer diagnosis and prognosis. Polygenic risk scores can predict genetic risk of a prostate cancer diagnosis. Although these scores inform the probability of developing a tumor, it remains unknown how germline risk influences the tumor molecular evolution. We cultivated a cohort of 1250 localized...
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