Article

High-Fidelity Nanopore Sequencing of Ultra-Short DNA Sequences

2019-02-16

Abstract excerpt

Nanopore sequencing offers a portable and affordable alternative to sequencing-by-synthesis methods but suffers from lower accuracy and cannot sequence ultra-short DNA. This puts applications such as molecular diagnostics based on the analysis of cell-free DNA or single-nucleotide variants (SNV) out of reach. To overcome these limitations, we report a nanopore-based sequencing strategy in which short target sequen...

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Literature Corpus work: ef752385-461c-584c-bacd-04e62f8d00b5
DOI: 10.1101/552224

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