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Advances in Genotyping Detection of Fragmented Nucleic Acids.

Biosensors - 28 Sept 2024

Liu Qian, Chen Yun, Qi Hao

Abstract excerpt

Single nucleotide variant (SNV) detection is pivotal in various fields, including disease diagnosis, viral screening, genetically modified organism (GMO) identification, and genotyping. However, detecting SNVs presents significant challenges due to the fragmentation of nucleic acids caused by cellular apoptosis, molecular shearing, and physical degradation processes such as heating. Fragmented nucleic acids often...

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PMID: 39451678
DOI: 10.3390/bios14100465
PMCID: PMC11506436

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