Article

MYC amplification at diagnosis drives therapy-induced hypermutation of recurrent glioma

2021-01-05

Abstract excerpt

<title>Abstract</title> <p>Clonal evolution drives cancer progression and therapeutic resistance<sup>1-2</sup>. Recent longitudinal analyses revealed divergent clonal dynamics in adult diffuse gliomas<sup>3–11</sup>. However, the early genomic and epigenomic factors that steer post-treatment molecular trajectories remain unknown. To track evolutionary predictors, we analyzed sequencing and clinical data of matche...

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Literature Corpus work: fcdef4e1-eadc-5524-8f71-b73e64ff1aec
DOI: 10.21203/rs.3.rs-138020/v1

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