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Whole exome sequencing reveals the genetic heterogeneity and evolutionary history of primary gliomas and matched recurrences

1 Jan 2022

Abstract excerpt

Diffuse glioma is a highly heterogeneous central nervous system tumor that is refractory to conventional therapy. Residual glioma cells escape from surgery and chemoradiotherapy, leading to lethal recurrence. Understanding the molecular mechanism of this recurrence process is critical to the development of successful therapies. Here, we analyzed whole-exome sequencing (WES) data of 97 paired primary and recurrent...

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PMID: 35615029
DOI: 10.1016/j.csbj.2022.04.034

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