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Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

12 Dec 2013

Abstract excerpt

Tumor recurrence is a leading cause of cancer mortality. Therapies for recurrent disease may fail, at least in part, because the genomic alterations driving the growth of recurrences are distinct from those in the initial tumor. To explore this hypothesis, we sequenced the exomes of 23 initial low-grade gliomas and recurrent tumors resected from the same patients. In 43% of cases, at least half of the mutations...

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PMID: 24336570
DOI: 10.1126/science.1239947

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