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Article

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

2021-05-04

Abstract excerpt

<h4>Summary</h4> To interrogate the factors driving therapy resistance in diffuse glioma, we collected and analyzed RNA and/or DNA sequencing data from temporally separated tumor pairs of 292 adult patients with IDH-wild-type or IDH-mutant glioma. Tumors recurred in distinct manners that were dependent on IDH mutation status and attributable to changes in histological feature composition, somatic alterations, and...

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Literature Corpus work
ea9944df-f254-5e2d-a2b8-5f9f9d1ea18e
DOI
10.1101/2021.05.03.442486
Open publication

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Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironmentDOI 10.1101/2021.05.03.442486
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