Identifying predictors of glioma evolution from longitudinal sequencing.

doi:10.1126/scitranslmed.adh4181

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Article

Identifying predictors of glioma evolution from longitudinal sequencing.

Science translational medicine - 4 Oct 2023

Mu Quanhua, Chai Ruichao, Pang Bo, Yang Yingxi, Liu Hanjie, Zhao Zheng, Bao Zhaoshi, Song Dong, Zhu Zhihan, Yan Mengli, Jiang Biaobin, Mo Zongchao, Tang Jihong, Sa Jason K, Cho Hee Jin, Chang Yuzhou, Chan Kaitlin Hao Yi, Loi Danson Shek Chun, Tam Sindy Sing Ting, Chan Aden Ka Yin, Wu Angela Ruohao, Liu Zhaoqi, Poon Wai Sang, Ng Ho Keung, Chan Danny Tat Ming, Iavarone Antonio, Nam Do-Hyun, Jiang Tao, Wang Jiguang

Abstract excerpt

Clonal evolution drives cancer progression and therapeutic resistance. Recent studies have revealed divergent longitudinal trajectories in gliomas, but early molecular features steering posttreatment cancer evolution remain unclear. Here, we collected sequencing and clinical data of initial-recurrent tumor pairs from 544 adult diffuse gliomas and performed multivariate analysis to identify early molecular...

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PMID: 37792958
DOI: 10.1126/scitranslmed.adh4181

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