Article
Mutational landscape and clonal architecture in grade II and III gliomas.
Nature genetics - 1 May 2015
Suzuki Hiromichi, Aoki Kosuke, Chiba Kenichi, Sato Yusuke, Shiozawa Yusuke, Shiraishi Yuichi, Shimamura Teppei, Niida Atsushi, Motomura Kazuya, Ohka Fumiharu, Yamamoto Takashi, Tanahashi Kuniaki, Ranjit Melissa, Wakabayashi Toshihiko, Yoshizato Tetsuichi, Kataoka Keisuke, Yoshida Kenichi, Nagata Yasunobu, Sato-Otsubo Aiko, Tanaka Hiroko, Sanada Masashi, Kondo Yutaka, Nakamura Hideo, Mizoguchi Masahiro, Abe Tatsuya, Muragaki Yoshihiro, Watanabe Reiko, Ito Ichiro, Miyano Satoru, Natsume Atsushi, Ogawa Seishi
Abstract excerpt
Grade II and III gliomas are generally slowly progressing brain cancers, many of which eventually transform into more aggressive tumors. Despite recent findings of frequent mutations in IDH1 and other genes, knowledge about their pathogenesis is still incomplete. Here, combining two large sets of high-throughput sequencing data, we delineate the entire picture of genetic alterations and affected pathways in these...
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